Monitoring Cell Death in Regorafenib-Treated Experimental Colon Carcinomas Using Annexin-Based Optical Fluorescence Imaging Validated by Perfusion MRI

Philipp M. Kazmierczak; Egon Burian; Ralf Eschbach; Heidrun Hirner-Eppeneder; Matthias Moser; Lukas Havla; Michel Eisenblätter; Maximilian F. Reiser; Konstantin Nikolaou; Clemens C. Cyran

doi:10.1371/journal.pone.0138452

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Open Access

Peer-reviewed

Research Article

Monitoring Cell Death in Regorafenib-Treated Experimental Colon Carcinomas Using Annexin-Based Optical Fluorescence Imaging Validated by Perfusion MRI

Philipp M. Kazmierczak ,

* E-mail: philipp.kazmierczak@med.lmu.de

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Egon Burian,

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Ralf Eschbach,

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Heidrun Hirner-Eppeneder,

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Matthias Moser,

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Lukas Havla,

Affiliation Institute for Clinical Radiology, Josef-Lissner-Laboratory for Biomedical Imaging, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Michel Eisenblätter,

Affiliations Department of Clinical Radiology, University Hospital Münster, Münster, Germany, Comprehensive Cancer Imaging Centre, Division of Imaging Sciences & Biomedical Engineering, King’s College London, United Kingdom
⨯
Maximilian F. Reiser,

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Konstantin Nikolaou,

Affiliations Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany, Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany
⨯
Clemens C. Cyran

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯

Monitoring Cell Death in Regorafenib-Treated Experimental Colon Carcinomas Using Annexin-Based Optical Fluorescence Imaging Validated by Perfusion MRI

Philipp M. Kazmierczak,
Egon Burian,
Ralf Eschbach,
Heidrun Hirner-Eppeneder,
Matthias Moser,
Lukas Havla,
Michel Eisenblätter,
Maximilian F. Reiser,
Konstantin Nikolaou,
Clemens C. Cyran

Published: September 22, 2015
https://doi.org/10.1371/journal.pone.0138452

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