Source-Related Effects of Wastewater on Transcription Factor (AhR, CAR and PXR)-Mediated Induction of Gene Expression in Cultured Rat Hepatocytes and Their Association with the Prevalence of Antimicrobial-Resistant Escherichia coli

• Keerthi S. Guruge ,

  * E-mail: guruge@affrc.go.jp

  Affiliation Pathology and Pathophysiology Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

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• Noriko Yamanaka,

  Affiliation Pathology and Pathophysiology Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

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• Miyuki Sonobe,

  Affiliations Pathology and Pathophysiology Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan, Central Livestock Hygiene Service Center, Wakakusu, Saga, Japan

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• Wataru Fujizono,

  Affiliations Pathology and Pathophysiology Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan, Central Livestock Hygiene Service Center, Jonan, Minami-Ku, Kumamoto, Japan

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• Miyako Yoshioka,

  Affiliation Pathology and Pathophysiology Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

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• Masato Akiba,

  Affiliation Bacterial and Parasitic Disease Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

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• Takehisa Yamamoto,

  Affiliation Viral Diseases and Epidemiology Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

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• Derrick I. Joshua,

  Affiliation Department of Civil Engineering, Manipal Institute of Technology, Manipal University, Manipal, Karnataka, India

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• Keshava Balakrishna,

  Affiliation Department of Civil Engineering, Manipal Institute of Technology, Manipal University, Manipal, Karnataka, India

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• Nobuyoshi Yamashita,

  Affiliation National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan

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• Kurunthachalam Kannan,

  Affiliation Wadsworth Center, New York State Department of Health and Department of Environmental Health Sciences, State University of New York at Albany, Albany, New York, United States of America

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• Toshiyuki Tsutsui

  Affiliation Viral Diseases and Epidemiology Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

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