Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser315

Rose E. Jeeves; Alice A. N. Marriott; Steven T. Pullan; Kim A. Hatch; Jon C. Allnutt; Irene Freire-Martin; Charlotte L. Hendon-Dunn; Robert Watson; Adam A. Witney; Richard H. Tyler; Catherine Arnold; Philip D. Marsh; Timothy D. McHugh; Joanna Bacon

doi:10.1371/journal.pone.0138253

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Open Access

Peer-reviewed

Research Article

Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser³¹⁵

Rose E. Jeeves ,

Contributed equally to this work with: Rose E. Jeeves, Alice A. N. Marriott

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯
Alice A. N. Marriott ,

Contributed equally to this work with: Rose E. Jeeves, Alice A. N. Marriott

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯
Steven T. Pullan,

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯
Kim A. Hatch †,

† Deceased.

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯
Jon C. Allnutt,

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯
Irene Freire-Martin,

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯
Charlotte L. Hendon-Dunn,

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯
Robert Watson,

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯
Adam A. Witney,

Affiliation St George's, University of London, Cranmer Terrace, London, United Kingdom
⨯
Richard H. Tyler,

Affiliation St George's, University of London, Cranmer Terrace, London, United Kingdom
⨯
Catherine Arnold,

Affiliation Public Health England, Colindale, 61 Colindale Avenue, London, United Kingdom
⨯
Philip D. Marsh,

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯
Timothy D. McHugh,

Affiliation University College London, Centre for Clinical Microbiology, Royal Free Campus, Rowland Hill Street, London, United Kingdom
⨯
Joanna Bacon

* E-mail: joanna.bacon@phe.gov.uk

Affiliation Public Health England, Porton Down, Salisbury, United Kingdom
⨯

Mycobacterium tuberculosis Is Resistant to Isoniazid at a Slow Growth Rate by Single Nucleotide Polymorphisms in katG Codon Ser³¹⁵

Rose E. Jeeves,
Alice A. N. Marriott,
Steven T. Pullan,
Kim A. Hatch,
Jon C. Allnutt,
Irene Freire-Martin,
Charlotte L. Hendon-Dunn,
Robert Watson,
Adam A. Witney,
Richard H. Tyler

Published: September 18, 2015
https://doi.org/10.1371/journal.pone.0138253

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Mycobacterium tuberculosis
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