Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma

Adil Doganay Duru; Tolga Sutlu; Ann Wallblom; Katarina Uttervall; Johan Lund; Birgitta Stellan; Gösta Gahrton; Hareth Nahi; Evren Alici

doi:10.1371/journal.pone.0138248

Loading metrics

Open Access

Peer-reviewed

Research Article

Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma

Adil Doganay Duru ,

Contributed equally to this work with: Adil Doganay Duru, Tolga Sutlu

Affiliations Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Center for Diseases of Aging, Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida, United States of America
⨯
Tolga Sutlu ,

Contributed equally to this work with: Adil Doganay Duru, Tolga Sutlu

Affiliations Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Nanotechnology Research and Application Center, Sabanci University, Istanbul, Turkey
⨯
Ann Wallblom,

Affiliation Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Katarina Uttervall,

Affiliations Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Haematology Centre, Karolinska University Hospital, Huddinge, Stockholm, Sweden
⨯
Johan Lund,

Affiliations Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Haematology Centre, Karolinska University Hospital, Huddinge, Stockholm, Sweden
⨯
Birgitta Stellan,

Affiliation Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Gösta Gahrton,

Affiliations Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Haematology Centre, Karolinska University Hospital, Huddinge, Stockholm, Sweden
⨯
Hareth Nahi ,

¶‡ These authors also contributed equally to this work.

Affiliations Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Haematology Centre, Karolinska University Hospital, Huddinge, Stockholm, Sweden
⨯
Evren Alici

* E-mail: evren.alici@ki.se

¶‡ These authors also contributed equally to this work.

Affiliations Center for Hematology and Regenerative Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden, Center for Diseases of Aging, Vaccine and Gene Therapy Institute of Florida, Port St. Lucie, Florida, United States of America, Haematology Centre, Karolinska University Hospital, Huddinge, Stockholm, Sweden
⨯

Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma

Adil Doganay Duru,
Tolga Sutlu,
Ann Wallblom,
Katarina Uttervall,
Johan Lund,
Birgitta Stellan,
Gösta Gahrton,
Hareth Nahi,
Evren Alici

Published: September 17, 2015
https://doi.org/10.1371/journal.pone.0138248

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Multiple myeloma
Is the Subject Area "Multiple myeloma" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Myeloma cells
Is the Subject Area "Myeloma cells" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Chromosomal deletions
Is the Subject Area "Chromosomal deletions" applicable to this article?

Thanks for your feedback.
Plasma cells
Is the Subject Area "Plasma cells" applicable to this article?

Thanks for your feedback.