Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker

Yukihiro Saito; Kazufumi Nakamura; Masashi Yoshida; Hiroki Sugiyama; Tohru Ohe; Junko Kurokawa; Tetsushi Furukawa; Makoto Takano; Satoshi Nagase; Hiroshi Morita; Kengo F. Kusano; Hiroshi Ito

doi:10.1371/journal.pone.0138193

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Open Access

Peer-reviewed

Research Article

Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker

Yukihiro Saito,

Affiliation Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Kazufumi Nakamura ,

* E-mail: ichibun@cc.okayama-u.ac.jp

Affiliation Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Masashi Yoshida,

Affiliation Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Hiroki Sugiyama,

Affiliation Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Tohru Ohe,

Affiliation Sakakibara Heart Institute of Okayama, Okayama, Japan
⨯
Junko Kurokawa,

Affiliation Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
⨯
Tetsushi Furukawa,

Affiliation Department of Bio-informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
⨯
Makoto Takano,

Affiliation Department of Physiology, Kurume University School of Medicine, Kurume, Japan
⨯
Satoshi Nagase,

Affiliation Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Hiroshi Morita,

Affiliations Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯
Kengo F. Kusano,

Affiliation Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
⨯
Hiroshi Ito

Affiliation Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
⨯

Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker

Yukihiro Saito,
Kazufumi Nakamura,
Masashi Yoshida,
Hiroki Sugiyama,
Tohru Ohe,
Junko Kurokawa,
Tetsushi Furukawa,
Makoto Takano,
Satoshi Nagase,
Hiroshi Morita

Published: September 18, 2015
https://doi.org/10.1371/journal.pone.0138193

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