Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells

Nupur Nigam; Abhinav Grover; Sukriti Goyal; Shashank P. Katiyar; Priyanshu Bhargava; Pi-Chao Wang; Durai Sundar; Sunil C. Kaul; Renu Wadhwa

doi:10.1371/journal.pone.0138192

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Open Access

Peer-reviewed

Research Article

Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells

Nupur Nigam,

Affiliations Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
⨯
Abhinav Grover,

Affiliation School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
⨯
Sukriti Goyal,

Affiliation School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
⨯
Shashank P. Katiyar,

Affiliation Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology (IIT) Delhi, New Delhi, India
⨯
Priyanshu Bhargava,

Affiliations Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
⨯
Pi-Chao Wang,

Affiliation Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan
⨯
Durai Sundar,

Affiliation Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology (IIT) Delhi, New Delhi, India
⨯
Sunil C. Kaul ,

* E-mail: renu-wadhwa@aist.go.jp (RW); s-kaul@aist.go.jp (SCK)

Affiliation Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan
⨯
Renu Wadhwa

* E-mail: renu-wadhwa@aist.go.jp (RW); s-kaul@aist.go.jp (SCK)

Affiliation Drug Discovery and Assets Innovation Lab, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Biomedical Research Institute, National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan
⨯

Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells

Nupur Nigam,
Abhinav Grover,
Sukriti Goyal,
Shashank P. Katiyar,
Priyanshu Bhargava,
Pi-Chao Wang,
Durai Sundar,
Sunil C. Kaul,
Renu Wadhwa

Published: September 16, 2015
https://doi.org/10.1371/journal.pone.0138192

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