Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

Jinhu Xiong; Marilina Piemontese; Melda Onal; Josh Campbell; Joseph J. Goellner; Vladimir Dusevich; Lynda Bonewald; Stavros C. Manolagas; Charles A. O’Brien

doi:10.1371/journal.pone.0138189

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Peer-reviewed

Research Article

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

Jinhu Xiong,

Affiliations Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
⨯
Marilina Piemontese,

Affiliations Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
⨯
Melda Onal,

Affiliations Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
⨯
Josh Campbell,

Affiliations Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
⨯
Joseph J. Goellner,

Affiliations Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
⨯
Vladimir Dusevich,

Affiliation Department of Oral Biology, University of Missouri-Kansas City School of Dentistry, Kansas City, Missouri, United States of America
⨯
Lynda Bonewald,

Affiliation Department of Oral Biology, University of Missouri-Kansas City School of Dentistry, Kansas City, Missouri, United States of America
⨯
Stavros C. Manolagas,

Affiliations Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
⨯
Charles A. O’Brien

* E-mail: caobrien@uams.edu

Affiliations Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America, The Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America
⨯

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

Jinhu Xiong,
Marilina Piemontese,
Melda Onal,
Josh Campbell,
Joseph J. Goellner,
Vladimir Dusevich,
Lynda Bonewald,
Stavros C. Manolagas,
Charles A. O’Brien

Published: September 22, 2015
https://doi.org/10.1371/journal.pone.0138189

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