Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design

Micaela B. Reddy; Kuo-Hsiung Yang; Gauri Rao; Craig R. Rayner; Jing Nie; Chandrasena Pamulapati; Bindumadhav M. Marathe; Alan Forrest; Elena A. Govorkova

doi:10.1371/journal.pone.0138069

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Open Access

Peer-reviewed

Research Article

Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design

Micaela B. Reddy ,

* E-mail: micaela.reddy@arraybiopharma.com (MBR); elena.govorkova@stjude.org (EAG)

Current address: Department of Clinical Pharmacology, Array BioPharma, Boulder, Colorado, United States of America

Affiliation Department of Drug Metabolism and Pharmacokinetics, Hoffmann-La Roche Inc., Nutley, New Jersey, United States of America
⨯
Kuo-Hsiung Yang,

Current address: Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Affiliations Department of Drug Metabolism and Pharmacokinetics, Hoffmann-La Roche Inc., Nutley, New Jersey, United States of America, Department of Pharmacy Practice, University of Buffalo, Buffalo, New York, United States of America
⨯
Gauri Rao,

Affiliation Department of Pharmacy Practice, University of Buffalo, Buffalo, New York, United States of America
⨯
Craig R. Rayner,

Current address: d3 Medicine LLC, Parsippany, NJ, United States of America

Affiliation Department of Drug Metabolism and Pharmacokinetics, Hoffmann-La Roche Inc., Nutley, New Jersey, United States of America
⨯
Jing Nie,

Current address: Department of Clinical Pharmacology, Janssen, Beijing, China

Affiliation Department of Drug Metabolism and Pharmacokinetics, Hoffmann-La Roche Inc., Nutley, New Jersey, United States of America
⨯
Chandrasena Pamulapati,

Current address: Department of Clinical Pharmacology, Boehringer-Ingelheim, Ridgefield, Connecticut, United States of America

Affiliation Department of Drug Metabolism and Pharmacokinetics, Hoffmann-La Roche Inc., Nutley, New Jersey, United States of America
⨯
Bindumadhav M. Marathe,

Affiliation Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯
Alan Forrest,

Affiliation Department of Pharmacy Practice, University of Buffalo, Buffalo, New York, United States of America
⨯
Elena A. Govorkova

* E-mail: micaela.reddy@arraybiopharma.com (MBR); elena.govorkova@stjude.org (EAG)

Affiliation Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
⨯

Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design

Micaela B. Reddy,
Kuo-Hsiung Yang,
Gauri Rao,
Craig R. Rayner,
Jing Nie,
Chandrasena Pamulapati,
Bindumadhav M. Marathe,
Alan Forrest,
Elena A. Govorkova

Published: October 13, 2015
https://doi.org/10.1371/journal.pone.0138069

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