Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction

• Mariell Pettersson,

  Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96, Gothenburg, Sweden

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• Maria Quant,

  Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96, Gothenburg, Sweden

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• Jaeki Min,

  Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America

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• Luigi Iconaru,

  Affiliation Department of Structural Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America

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• Richard W. Kriwacki,

  Affiliation Department of Structural Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America

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• M. Brett Waddell,

  Affiliation Molecular Interaction Analysis Shared Resource, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America

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• R. Kiplin Guy,

  Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, 38105, United States of America

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• Kristina Luthman,

  Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96, Gothenburg, Sweden

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• Morten Grøtli

  * E-mail: grotli@chem.gu.se

  Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96, Gothenburg, Sweden

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