Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin

Audrey Laroche; Kevin Tran-Cong; Vanessa Chaire; Pauline Lagarde; Isabelle Hostein; Jean-Michel Coindre; Frederic Chibon; Agnes Neuville; Tom Lesluyes; Carlo Lucchesi; Antoine Italiano

doi:10.1371/journal.pone.0137794

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Open Access

Peer-reviewed

Research Article

Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin

Audrey Laroche,

Affiliations INSERM U916, Institut Bergonié, Bordeaux, France, Sarcoma Unit, Institut Bergonié, Bordeaux, France
⨯
Kevin Tran-Cong,

Affiliations INSERM U916, Institut Bergonié, Bordeaux, France, Sarcoma Unit, Institut Bergonié, Bordeaux, France
⨯
Vanessa Chaire,

Affiliations INSERM U916, Institut Bergonié, Bordeaux, France, Sarcoma Unit, Institut Bergonié, Bordeaux, France
⨯
Pauline Lagarde,

Affiliations INSERM U916, Institut Bergonié, Bordeaux, France, Sarcoma Unit, Institut Bergonié, Bordeaux, France
⨯
Isabelle Hostein,

Affiliation Pathology Department, Institut Bergonié, Bordeaux, France
⨯
Jean-Michel Coindre,

Affiliations Sarcoma Unit, Institut Bergonié, Bordeaux, France, Pathology Department, Institut Bergonié, Bordeaux, France
⨯
Frederic Chibon,

Affiliations INSERM U916, Institut Bergonié, Bordeaux, France, Sarcoma Unit, Institut Bergonié, Bordeaux, France
⨯
Agnes Neuville,

Affiliations Sarcoma Unit, Institut Bergonié, Bordeaux, France, Pathology Department, Institut Bergonié, Bordeaux, France
⨯
Tom Lesluyes,

Affiliations INSERM U916, Institut Bergonié, Bordeaux, France, Sarcoma Unit, Institut Bergonié, Bordeaux, France
⨯
Carlo Lucchesi,

Affiliations INSERM U916, Institut Bergonié, Bordeaux, France, Sarcoma Unit, Institut Bergonié, Bordeaux, France
⨯
Antoine Italiano

* E-mail: a.italiano@bordeaux.unicancer.fr

Affiliations INSERM U916, Institut Bergonié, Bordeaux, France, Sarcoma Unit, Institut Bergonié, Bordeaux, France
⨯

Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin

Audrey Laroche,
Kevin Tran-Cong,
Vanessa Chaire,
Pauline Lagarde,
Isabelle Hostein,
Jean-Michel Coindre,
Frederic Chibon,
Agnes Neuville,
Tom Lesluyes,
Carlo Lucchesi

Published: October 1, 2015
https://doi.org/10.1371/journal.pone.0137794

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