ER Stress Mediates TiAl6V4 Particle-Induced Peri-Implant Osteolysis by Promoting RANKL Expression in Fibroblasts

Zhenheng Wang; Naicheng Liu; Tongguo Shi; Gang Zhou; Zhenzhen Wang; Jingjing Gan; Ting Guo; Hongbo Qian; Nirong Bao; Jianning Zhao

doi:10.1371/journal.pone.0137774

Loading metrics

Open Access

Peer-reviewed

Research Article

ER Stress Mediates TiAl₆V₄ Particle-Induced Peri-Implant Osteolysis by Promoting RANKL Expression in Fibroblasts

Zhenheng Wang,

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯
Naicheng Liu,

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯
Tongguo Shi,

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯
Gang Zhou,

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯
Zhenzhen Wang,

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯
Jingjing Gan,

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯
Ting Guo,

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯
Hongbo Qian ,

* E-mail: qianrenyang@vip.163.com (HQ); bnrbnr@sina.com (NB); zhaojianning.0207@163.com (JZ)

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯
Nirong Bao ,

* E-mail: qianrenyang@vip.163.com (HQ); bnrbnr@sina.com (NB); zhaojianning.0207@163.com (JZ)

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯
Jianning Zhao

* E-mail: qianrenyang@vip.163.com (HQ); bnrbnr@sina.com (NB); zhaojianning.0207@163.com (JZ)

Affiliation Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
⨯

ER Stress Mediates TiAl₆V₄ Particle-Induced Peri-Implant Osteolysis by Promoting RANKL Expression in Fibroblasts

Zhenheng Wang,
Naicheng Liu,
Tongguo Shi,
Gang Zhou,
Zhenzhen Wang,
Jingjing Gan,
Ting Guo,
Hongbo Qian,
Nirong Bao,
Jianning Zhao

Published: September 14, 2015
https://doi.org/10.1371/journal.pone.0137774

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Endoplasmic reticulum
Is the Subject Area "Endoplasmic reticulum" applicable to this article?

Thanks for your feedback.
Osteoclasts
Is the Subject Area "Osteoclasts" applicable to this article?

Thanks for your feedback.
Bone resorption
Is the Subject Area "Bone resorption" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Nanoparticles
Is the Subject Area "Nanoparticles" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.