Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

Open Access

Peer-reviewed

Research Article

Martina Korhonova,

Affiliation Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic
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Aneta Doricakova,

Affiliation Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic
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Zdenek Dvorak

* E-mail: moulin@email.cz

Affiliation Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71, Olomouc, Czech Republic
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Statins
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Enantiomers
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Hepatocytes
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Isomers
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Luciferase
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Transfection
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Drug-drug interactions
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Transcriptional control
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