Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes

Helen P. McWilliams-Koeppen; James S. Foster; Nicole Hackenbrack; Marina Ramirez-Alvarado; Dallas Donohoe; Angela Williams; Sallie Macy; Craig Wooliver; Dale Wortham; Jennifer Morrell-Falvey; Carmen M. Foster; Stephen J. Kennel; Jonathan S. Wall

doi:10.1371/journal.pone.0137716

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Open Access

Peer-reviewed

Research Article

Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes

Helen P. McWilliams-Koeppen,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America
⨯
James S. Foster,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America
⨯
Nicole Hackenbrack,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America
⨯
Marina Ramirez-Alvarado,

Affiliation Department of Biochemistry/Mol. Biol. and Immunology, Mayo Clinic, Rochester, MN, United States of America
⨯
Dallas Donohoe,

Affiliation Department of Nutrition, University of Tennessee Knoxville, TN, United States of America
⨯
Angela Williams,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America
⨯
Sallie Macy,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America
⨯
Craig Wooliver,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America
⨯
Dale Wortham,

Affiliation Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America
⨯
Jennifer Morrell-Falvey,

Affiliation Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States of America
⨯
Carmen M. Foster,

Affiliation Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States of America
⨯
Stephen J. Kennel,

Affiliations Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America, Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America
⨯
Jonathan S. Wall

* E-mail: jwall@utmck.edu

Affiliations Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America, Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN United States of America
⨯

Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes

Helen P. McWilliams-Koeppen,
James S. Foster,
Nicole Hackenbrack,
Marina Ramirez-Alvarado,
Dallas Donohoe,
Angela Williams,
Sallie Macy,
Craig Wooliver,
Dale Wortham,
Jennifer Morrell-Falvey

Published: September 22, 2015
https://doi.org/10.1371/journal.pone.0137716

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Cardiomyocytes
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MTT assay
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Monomers
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Amyloid proteins
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Protein metabolism
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Cell metabolism
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Oxygen consumption
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Cardiomyopathies
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