Enhanced Production of Androst-1,4-Diene-3,17-Dione by Mycobacterium neoaurum JC-12 Using Three-Stage Fermentation Strategy

Minglong Shao; Xian Zhang; Zhiming Rao; Meijuan Xu; Taowei Yang; Hui Li; Zhenghong Xu

doi:10.1371/journal.pone.0137658

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Peer-reviewed

Research Article

Enhanced Production of Androst-1,4-Diene-3,17-Dione by Mycobacterium neoaurum JC-12 Using Three-Stage Fermentation Strategy

Minglong Shao,

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, Laboratory of Applied Microorganisms and Metabolic Engineering, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province, 214122, P. R. China
⨯
Xian Zhang,

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, Laboratory of Applied Microorganisms and Metabolic Engineering, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province, 214122, P. R. China
⨯
Zhiming Rao ,

* E-mail: raozhm@jiangnan.edu.cn

Current Address: School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, 214122, P. R. China

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, Laboratory of Applied Microorganisms and Metabolic Engineering, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province, 214122, P. R. China
⨯
Meijuan Xu,

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, Laboratory of Applied Microorganisms and Metabolic Engineering, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province, 214122, P. R. China
⨯
Taowei Yang,

Affiliation The Key Laboratory of Industrial Biotechnology, Ministry of Education, Laboratory of Applied Microorganisms and Metabolic Engineering, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province, 214122, P. R. China
⨯
Hui Li,

Affiliation Laboratory of Pharmaceutical Engineering, School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu Province, 214122, P. R. China
⨯
Zhenghong Xu

Affiliation Laboratory of Pharmaceutical Engineering, School of Pharmaceutical Science, Jiangnan University, Wuxi, Jiangsu Province, 214122, P. R. China
⨯

Enhanced Production of Androst-1,4-Diene-3,17-Dione by Mycobacterium neoaurum JC-12 Using Three-Stage Fermentation Strategy

Minglong Shao,
Xian Zhang,
Zhiming Rao,
Meijuan Xu,
Taowei Yang,
Hui Li,
Zhenghong Xu

Published: September 9, 2015
https://doi.org/10.1371/journal.pone.0137658

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