Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice

Steven D. Schutt; Jianing Fu; Hung Nguyen; David Bastian; Jessica Heinrichs; Yongxia Wu; Chen Liu; Daniel G. McDonald; Joseph Pidala; Xue-Zhong Yu

doi:10.1371/journal.pone.0137641

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Open Access

Peer-reviewed

Research Article

Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice

Steven D. Schutt ,

Contributed equally to this work with: Steven D. Schutt, Jianing Fu

Affiliation Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Jianing Fu ,

Contributed equally to this work with: Steven D. Schutt, Jianing Fu

Affiliations Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America, Cancer Biology PhD Program, University of South Florida and H. Lee Moffitt Cancer Center, Tampa, Florida, United States of America
⨯
Hung Nguyen,

Affiliation Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
David Bastian,

Affiliation Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Jessica Heinrichs,

Affiliation Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Yongxia Wu,

Affiliation Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Chen Liu,

Affiliation Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Daniel G. McDonald,

Affiliation Department of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Joseph Pidala,

Affiliation Blood and Bone Marrow Transplant Department, Moffitt Cancer Center, Tampa, Florida, United States of America
⨯
Xue-Zhong Yu

* E-mail: yux@musc.edu

Affiliations Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, United States of America, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯

Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice

Steven D. Schutt,
Jianing Fu,
Hung Nguyen,
David Bastian,
Jessica Heinrichs,
Yongxia Wu,
Chen Liu,
Daniel G. McDonald,
Joseph Pidala,
Xue-Zhong Yu

Published: September 8, 2015
https://doi.org/10.1371/journal.pone.0137641

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