Multidimensional Clusters of CD4+ T Cell Dysfunction Are Primarily Associated with the CD4/CD8 Ratio in Chronic HIV Infection

Juliet Frederiksen; Marcus Buggert; Kajsa Noyan; Piotr Nowak; Anders Sönnerborg; Ole Lund; Annika C. Karlsson

doi:10.1371/journal.pone.0137635

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Open Access

Peer-reviewed

Research Article

Multidimensional Clusters of CD4+ T Cell Dysfunction Are Primarily Associated with the CD4/CD8 Ratio in Chronic HIV Infection

Juliet Frederiksen ,

Contributed equally to this work with: Juliet Frederiksen, Marcus Buggert

Affiliation Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
⨯
Marcus Buggert ,

Contributed equally to this work with: Juliet Frederiksen, Marcus Buggert

* E-mail: marcus.buggert@ki.se

Affiliations Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Kajsa Noyan,

Affiliation Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
⨯
Piotr Nowak,

Affiliations Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Anders Sönnerborg,

Affiliations Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Ole Lund,

Affiliation Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
⨯
Annika C. Karlsson

Affiliation Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
⨯

Multidimensional Clusters of CD4+ T Cell Dysfunction Are Primarily Associated with the CD4/CD8 Ratio in Chronic HIV Infection

Juliet Frederiksen,
Marcus Buggert,
Kajsa Noyan,
Piotr Nowak,
Anders Sönnerborg,
Ole Lund,
Annika C. Karlsson

Published: September 24, 2015
https://doi.org/10.1371/journal.pone.0137635

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HIV infections
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HIV
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