Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor

Qinhui Zhang; Yingjie Du; Jianliang Zhang; Xiaojun Xu; Fenqin Xue; Cong Guo; Yao Huang; Ronald J. Lukas; Yongchang Chang

doi:10.1371/journal.pone.0137588

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Open Access

Peer-reviewed

Research Article

Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor

Qinhui Zhang,

Affiliations Department of Zoology, College of Life Sciences, Sichuan University, Chengdu, Sichuan Province, 610064, China, Chengdu institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China, Division of Neurobiology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona 85013, United States of America
⨯
Yingjie Du,

Affiliation University of California Los Angeles, Henry Samueli School of Engineering and Applied Science, Los Angeles, California 90095, United States of America
⨯
Jianliang Zhang,

Affiliations Division of Neurobiology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona 85013, United States of America, Department of Neurobiology, Beijing Institute of Brain Disorders, Capital Medical University, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Center of Neural Regeneration and Repair, Beijing Key Laboratory of Brain Major Disorders; State Key Lab Incubation Base, Beijing Neuroscience Disciplines, Beijing 100069, China
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Xiaojun Xu,

Affiliation Division of Neurobiology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona 85013, United States of America
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Fenqin Xue,

Affiliations Division of Neurobiology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona 85013, United States of America, Core Facilities for Electrophysiology, Core Facilities Center, Capital Medical University, Beijing 100069, China
⨯
Cong Guo,

Affiliations Department of Zoology, College of Life Sciences, Sichuan University, Chengdu, Sichuan Province, 610064, China, Chengdu institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China
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Yao Huang,

Affiliation Department of Obstetrics and Gynecology, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona 85013, United States of America
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Ronald J. Lukas,

Affiliation Division of Neurobiology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona 85013, United States of America
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Yongchang Chang

* E-mail: yongchang.chang@dignityhealth.org

Affiliation Division of Neurobiology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona 85013, United States of America
⨯

Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor

Qinhui Zhang,
Yingjie Du,
Jianliang Zhang,
Xiaojun Xu,
Fenqin Xue,
Cong Guo,
Yao Huang,
Ronald J. Lukas,
Yongchang Chang

Published: September 4, 2015
https://doi.org/10.1371/journal.pone.0137588

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Nicotinic acetylcholine receptors
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Single nucleotide polymorphisms
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Missense mutation
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