A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Metformin Therapy in Overweight/Obese Youth with Type 1 Diabetes

Benjamin Udoka Nwosu; Louise Maranda; Karen Cullen; Lisa Greenman; Jody Fleshman; Nancy McShea; Bruce A. Barton; Mary M. Lee

doi:10.1371/journal.pone.0137525

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Open Access

Peer-reviewed

Research Article

A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Metformin Therapy in Overweight/Obese Youth with Type 1 Diabetes

Benjamin Udoka Nwosu ,

* E-mail: Benjamin.Nwosu@umassmemorial.org

Affiliation Division of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, Massachusetts, 01655, United States of America
⨯
Louise Maranda,

Affiliation Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, Massachusetts, 01655, United States of America
⨯
Karen Cullen,

Affiliation Division of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, Massachusetts, 01655, United States of America
⨯
Lisa Greenman,

Affiliation Division of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, Massachusetts, 01655, United States of America
⨯
Jody Fleshman,

Affiliation Division of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, Massachusetts, 01655, United States of America
⨯
Nancy McShea,

Affiliation Division of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, Massachusetts, 01655, United States of America
⨯
Bruce A. Barton,

Affiliation Department of Quantitative Health Sciences, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, Massachusetts, 01655, United States of America
⨯
Mary M. Lee

Affiliation Division of Pediatric Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, Massachusetts, 01655, United States of America
⨯

A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Metformin Therapy in Overweight/Obese Youth with Type 1 Diabetes

Benjamin Udoka Nwosu,
Louise Maranda,
Karen Cullen,
Lisa Greenman,
Jody Fleshman,
Nancy McShea,
Bruce A. Barton,
Mary M. Lee

Published: September 14, 2015
https://doi.org/10.1371/journal.pone.0137525

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