Dual Functions of the RFTS Domain of Dnmt1 in Replication-Coupled DNA Methylation and in Protection of the Genome from Aberrant Methylation

Ronald Garingalao Garvilles; Takashi Hasegawa; Hironobu Kimura; Jafar Sharif; Masahiro Muto; Haruhiko Koseki; Saori Takahashi; Isao Suetake; Shoji Tajima

doi:10.1371/journal.pone.0137509

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Open Access

Peer-reviewed

Research Article

Dual Functions of the RFTS Domain of Dnmt1 in Replication-Coupled DNA Methylation and in Protection of the Genome from Aberrant Methylation

Ronald Garingalao Garvilles ,

Contributed equally to this work with: Ronald Garingalao Garvilles, Takashi Hasegawa

Affiliation Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka, 565-0871, Japan
⨯
Takashi Hasegawa ,

Contributed equally to this work with: Ronald Garingalao Garvilles, Takashi Hasegawa

Affiliation Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka, 565-0871, Japan
⨯
Hironobu Kimura,

Affiliation Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka, 565-0871, Japan
⨯
Jafar Sharif,

Affiliation RIKEN Center for Interactive Medical Sciences, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan
⨯
Masahiro Muto,

Affiliation RIKEN Center for Interactive Medical Sciences, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan
⨯
Haruhiko Koseki,

Affiliation RIKEN Center for Interactive Medical Sciences, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan
⨯
Saori Takahashi,

Affiliation Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka, 565-0871, Japan
⨯
Isao Suetake,

Affiliations Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka, 565-0871, Japan, CREST, JST, Saitama, 332-0012, Japan
⨯
Shoji Tajima

* E-mail: tajima@protein.osaka-u.ac.jp

Affiliation Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Yamadaoka, Suita, Osaka, 565-0871, Japan
⨯

Dual Functions of the RFTS Domain of Dnmt1 in Replication-Coupled DNA Methylation and in Protection of the Genome from Aberrant Methylation

Ronald Garingalao Garvilles,
Takashi Hasegawa,
Hironobu Kimura,
Jafar Sharif,
Masahiro Muto,
Haruhiko Koseki,
Saori Takahashi,
Isao Suetake,
Shoji Tajima

Published: September 18, 2015
https://doi.org/10.1371/journal.pone.0137509

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DNA replication
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Methylation
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