Regulatory Divergence of Transcript Isoforms in a Mammalian Model System

Sarah Leigh-Brown; Angela Goncalves; David Thybert; Klara Stefflova; Stephen Watt; Paul Flicek; Alvis Brazma; John C. Marioni; Duncan T. Odom

doi:10.1371/journal.pone.0137367

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Open Access

Peer-reviewed

Research Article

Regulatory Divergence of Transcript Isoforms in a Mammalian Model System

Sarah Leigh-Brown ,

Contributed equally to this work with: Sarah Leigh-Brown, Angela Goncalves

Affiliation University of Cambridge, Cancer Research UK - Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom
⨯
Angela Goncalves ,

Contributed equally to this work with: Sarah Leigh-Brown, Angela Goncalves

Affiliations European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
David Thybert,

Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Klara Stefflova,

Affiliation California Institute of Technology, Division of Biology, Pasadena, California, United States of America
⨯
Stephen Watt,

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Paul Flicek,

Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Alvis Brazma,

Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
John C. Marioni ,

* E-mail: Duncan.odom@cruk.cam.ac.uk (DTO); marioni@ebi.ac.uk (JCM)

Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Duncan T. Odom

* E-mail: Duncan.odom@cruk.cam.ac.uk (DTO); marioni@ebi.ac.uk (JCM)

Affiliations University of Cambridge, Cancer Research UK - Cambridge Institute, Li Ka Shing Centre, Cambridge, United Kingdom, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
⨯

Regulatory Divergence of Transcript Isoforms in a Mammalian Model System

Sarah Leigh-Brown,
Angela Goncalves,
David Thybert,
Klara Stefflova,
Stephen Watt,
Paul Flicek,
Alvis Brazma,
John C. Marioni,
Duncan T. Odom

Published: September 4, 2015
https://doi.org/10.1371/journal.pone.0137367

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Gene expression
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Gene regulation
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Polyadenylation
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Transcriptome analysis
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Site selection
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Genetic loci
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Transcriptional control
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Mammals
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