High-Throughput Screening for Ligands of the HEPN Domain of Sacsin

Open Access

Peer-reviewed

Research Article

Xinlu Li,

Affiliations Department of Biochemistry, McGill University, Montreal, Quebec, Canada, Groupe de recherche axé sur la structure des protéines, Montreal, Quebec, Canada
⨯
Marie Ménade,

Affiliations Department of Biochemistry, McGill University, Montreal, Quebec, Canada, Groupe de recherche axé sur la structure des protéines, Montreal, Quebec, Canada
⨯
Guennadi Kozlov,

Affiliations Department of Biochemistry, McGill University, Montreal, Quebec, Canada, Groupe de recherche axé sur la structure des protéines, Montreal, Quebec, Canada
⨯
Zheping Hu,

Affiliations Department of Biochemistry, McGill University, Montreal, Quebec, Canada, Groupe de recherche axé sur la structure des protéines, Montreal, Quebec, Canada
⨯
Zheng Dai,

Affiliations Department of Biochemistry, McGill University, Montreal, Quebec, Canada, Groupe de recherche axé sur la structure des protéines, Montreal, Quebec, Canada
⨯
Peter S. McPherson,

Affiliation Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
⨯
Bernard Brais,

Affiliation Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
⨯
Kalle Gehring

* E-mail: kalle.gehring@mcgill.ca

Affiliations Department of Biochemistry, McGill University, Montreal, Quebec, Canada, Groupe de recherche axé sur la structure des protéines, Montreal, Quebec, Canada
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Nucleotides
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Phosphates
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Crystal structure
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High throughput screening
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NMR spectroscopy
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Fluorescence polarization
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Nucleotide mapping
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Magnesium chloride
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