Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185

• Yoko Tabe ,

  Contributed equally to this work with: Yoko Tabe, Kensuke Kojima

  Affiliations Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America, Department of Clinical Laboratory Medicine, Biomedical Research Center Graduate School of Medicine, Juntendo University, Tokyo, Japan

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• Kensuke Kojima ,

  Contributed equally to this work with: Yoko Tabe, Kensuke Kojima

  Affiliation Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America

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• Shinichi Yamamoto,

  Affiliations Department of Clinical Laboratory Medicine, Biomedical Research Center Graduate School of Medicine, Juntendo University, Tokyo, Japan, Leading Center for the Development and Research of Cancer Medicine, Biomedical Research Center Graduate School of Medicine, Juntendo University, Tokyo, Japan

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• Kazumasa Sekihara,

  Affiliations Department of Clinical Laboratory Medicine, Biomedical Research Center Graduate School of Medicine, Juntendo University, Tokyo, Japan, Leading Center for the Development and Research of Cancer Medicine, Biomedical Research Center Graduate School of Medicine, Juntendo University, Tokyo, Japan

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• Hiromichi Matsushita,

  Affiliation Department of Laboratory Medicine, Tokai University of Medicine, Kanagawa, Japan

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• Richard Eric Davis,

  Affiliation Department of Lymphoma and Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America

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• Zhiqiang Wang,

  Affiliation Department of Lymphoma and Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America

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• Wencai Ma,

  Affiliation Department of Lymphoma and Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America

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• Jo Ishizawa,

  Affiliation Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America

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• Saiko Kazuno,

  Affiliation Laboratory of Proteomics and Biomolecular Science, Biomedical Research Center Graduate School of Medicine, Juntendo University, Tokyo, Japan

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• Michael Kauffman,

  Affiliation Karyopharm Therapeutics Inc., Natick, MA, United States of America

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• Sharon Shacham,

  Affiliation Karyopharm Therapeutics Inc., Natick, MA, United States of America

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• Tsutomu Fujimura,

  Affiliation Laboratory of Proteomics and Biomolecular Science, Biomedical Research Center Graduate School of Medicine, Juntendo University, Tokyo, Japan

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• Takashi Ueno,

  Affiliation Laboratory of Proteomics and Biomolecular Science, Biomedical Research Center Graduate School of Medicine, Juntendo University, Tokyo, Japan

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• Takashi Miida,

  Affiliation Department of Clinical Laboratory Medicine, Biomedical Research Center Graduate School of Medicine, Juntendo University, Tokyo, Japan

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•  [ ... ],
• Michael Andreeff

  * E-mail: mandreef@mdanderson.org

  Affiliation Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States of America

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