Altered Expression of Wnt Signaling Pathway Components in Osteogenesis of Mesenchymal Stem Cells in Osteoarthritis Patients

Pilar Tornero-Esteban; Ascensión Peralta-Sastre; Eva Herranz; Luis Rodríguez-Rodríguez; Arkaitz Mucientes; Lydia Abásolo; Fernando Marco; Benjamín Fernández-Gutiérrez; José Ramón Lamas

doi:10.1371/journal.pone.0137170

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Open Access

Peer-reviewed

Research Article

Altered Expression of Wnt Signaling Pathway Components in Osteogenesis of Mesenchymal Stem Cells in Osteoarthritis Patients

Pilar Tornero-Esteban ,

Contributed equally to this work with: Pilar Tornero-Esteban, Ascensión Peralta-Sastre

Affiliation Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), UGC Reumatología, Hospital Clínico San Carlos, 4ª Planta, Ala Norte, C/ Profesor Martín Lagos s/n, 28040, Madrid, Spain
⨯
Ascensión Peralta-Sastre ,

Contributed equally to this work with: Pilar Tornero-Esteban, Ascensión Peralta-Sastre

Affiliation Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), UGC Reumatología, Hospital Clínico San Carlos, 4ª Planta, Ala Norte, C/ Profesor Martín Lagos s/n, 28040, Madrid, Spain
⨯
Eva Herranz,

Affiliation Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), UGC Reumatología, Hospital Clínico San Carlos, 4ª Planta, Ala Norte, C/ Profesor Martín Lagos s/n, 28040, Madrid, Spain
⨯
Luis Rodríguez-Rodríguez,

Affiliation Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), UGC Reumatología, Hospital Clínico San Carlos, 4ª Planta, Ala Norte, C/ Profesor Martín Lagos s/n, 28040, Madrid, Spain
⨯
Arkaitz Mucientes,

Affiliation Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), UGC Reumatología, Hospital Clínico San Carlos, 4ª Planta, Ala Norte, C/ Profesor Martín Lagos s/n, 28040, Madrid, Spain
⨯
Lydia Abásolo,

Affiliation Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), UGC Reumatología, Hospital Clínico San Carlos, 4ª Planta, Ala Norte, C/ Profesor Martín Lagos s/n, 28040, Madrid, Spain
⨯
Fernando Marco,

Affiliation Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), UGC Traumatología, Hospital Clínico San Carlos, 6ª Planta, Ala Norte, C/ Profesor Martín Lagos s/n, 28040, Madrid, Spain
⨯
Benjamín Fernández-Gutiérrez ,

¶‡ Authors share co-authorship.

Affiliation Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), UGC Reumatología, Hospital Clínico San Carlos, 4ª Planta, Ala Norte, C/ Profesor Martín Lagos s/n, 28040, Madrid, Spain
⨯
José Ramón Lamas

* E-mail: jrlamas@gmail.com

¶‡ Authors share co-authorship.

Affiliation Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), UGC Reumatología, Hospital Clínico San Carlos, 4ª Planta, Ala Norte, C/ Profesor Martín Lagos s/n, 28040, Madrid, Spain
⨯

Altered Expression of Wnt Signaling Pathway Components in Osteogenesis of Mesenchymal Stem Cells in Osteoarthritis Patients

Pilar Tornero-Esteban,
Ascensión Peralta-Sastre,
Eva Herranz,
Luis Rodríguez-Rodríguez,
Arkaitz Mucientes,
Lydia Abásolo,
Fernando Marco,
Benjamín Fernández-Gutiérrez,
José Ramón Lamas

Published: September 9, 2015
https://doi.org/10.1371/journal.pone.0137170

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Wnt signaling cascade
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MAPK signaling cascades
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Osteoarthritis
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Gene expression
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Cell differentiation
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Gene regulation
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