Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution

• Eva M. Schmidt ,

  Contributed equally to this work with: Eva M. Schmidt, Constanze Wiek

  Affiliation Department of Pediatric Hematology, Oncology and Clinical Immunology, Children’s Hospital, Heinrich Heine University, 40225 Düsseldorf, Germany

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• Constanze Wiek ,

  Contributed equally to this work with: Eva M. Schmidt, Constanze Wiek

  Affiliation Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany

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• Oliver T. Parkinson,

  Affiliation Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195, United States of America

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• Katharina Roellecke,

  Affiliation Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany

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• Marcel Freund,

  Affiliation Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany

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• Michael Gombert,

  Affiliation Department of Pediatric Hematology, Oncology and Clinical Immunology, Children’s Hospital, Heinrich Heine University, 40225 Düsseldorf, Germany

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• Nadine Lottmann,

  Affiliation Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany

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• Charles A. Steward,

  Affiliation Wellcome Trust Sanger Institute, Cambridge, United Kingdom

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• Christof M. Kramm,

  Affiliation Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University of Göttingen, 37099 Göttingen, Germany

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• Vladimir Yarov-Yarovoy,

  Affiliation Departments of Physiology and Membrane Biology, University of California Davis, Davis, CA 95616, United States of America

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• Allan E. Rettie,

  Affiliation Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195, United States of America

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• Helmut Hanenberg

  * E-mail: Helmut.Hanenberg@uni-due.de

  Affiliations Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich Heine University, 40225 Düsseldorf, Germany, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, United States of America, Department of Pediatrics III, University Children’s Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany

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