A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling

Atsuko Nakayama; Hiroyuki Morita; Tomoko Nakao; Toshihiro Yamaguchi; Tomokazu Sumida; Yuichi Ikeda; Hidetoshi Kumagai; Yoshihiro Motozawa; Tsukasa Takahashi; Atsushi Imaizumi; Tadashi Hashimoto; Ryozo Nagai; Issei Komuro

doi:10.1371/journal.pone.0137106

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Open Access

Peer-reviewed

Research Article

A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling

Atsuko Nakayama ,

Contributed equally to this work with: Atsuko Nakayama, Hiroyuki Morita

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯
Hiroyuki Morita ,

Contributed equally to this work with: Atsuko Nakayama, Hiroyuki Morita

* E-mail: hmrt-tky@umin.net

Affiliation Department of Translational Research for Healthcare and Clinical Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯
Tomoko Nakao,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯
Toshihiro Yamaguchi,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯
Tomokazu Sumida,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯
Yuichi Ikeda,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯
Hidetoshi Kumagai,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯
Yoshihiro Motozawa,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯
Tsukasa Takahashi,

Affiliation Theravalues Corporation, Tokyo, Japan
⨯
Atsushi Imaizumi,

Affiliation Theravalues Corporation, Tokyo, Japan
⨯
Tadashi Hashimoto,

Affiliation Theravalues Corporation, Tokyo, Japan
⨯
Ryozo Nagai,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯
Issei Komuro

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⨯

A Food-Derived Flavonoid Luteolin Protects against Angiotensin II-Induced Cardiac Remodeling

Atsuko Nakayama,
Hiroyuki Morita,
Tomoko Nakao,
Toshihiro Yamaguchi,
Tomokazu Sumida,
Yuichi Ikeda,
Hidetoshi Kumagai,
Yoshihiro Motozawa,
Tsukasa Takahashi,
Atsushi Imaizumi

Published: September 1, 2015
https://doi.org/10.1371/journal.pone.0137106

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