G2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone Compound

Maia Cabrera; Natalia Gomez; Federico Remes Lenicov; Emiliana Echeverría; Carina Shayo; Albertina Moglioni; Natalia Fernández; Carlos Davio

doi:10.1371/journal.pone.0136878

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Open Access

Peer-reviewed

Research Article

G2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone Compound

Maia Cabrera ,

* E-mail: cabrera.maia@gmail.com

Affiliation Instituto de Investigaciones Farmacológicas, Facultad de Farmacia y Bioquímica (ININFA-UBA-CONICET), Buenos Aires, Argentina
⨯
Natalia Gomez,

Affiliations Instituto de Investigaciones Farmacológicas, Facultad de Farmacia y Bioquímica (ININFA-UBA-CONICET), Buenos Aires, Argentina, Cátedra de Química Medicinal, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
⨯
Federico Remes Lenicov,

Affiliation Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, Facultad de Medicina, (INBIRS-UBA-CONICET), Buenos Aires, Argentina
⨯
Emiliana Echeverría,

Affiliation Instituto de Investigaciones Farmacológicas, Facultad de Farmacia y Bioquímica (ININFA-UBA-CONICET), Buenos Aires, Argentina
⨯
Carina Shayo,

Affiliation Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina
⨯
Albertina Moglioni,

Affiliations Instituto de Química y Metabolismo del Fármaco, Facultad de Farmacia y Bioquímica, (IQUIMEFA-UBA-CONICET), Buenos Aires, Argentina, Cátedra de Química Medicinal, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
⨯
Natalia Fernández,

Affiliations Instituto de Investigaciones Farmacológicas, Facultad de Farmacia y Bioquímica (ININFA-UBA-CONICET), Buenos Aires, Argentina, Cátedra de Química Medicinal, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
⨯
Carlos Davio

Affiliations Instituto de Investigaciones Farmacológicas, Facultad de Farmacia y Bioquímica (ININFA-UBA-CONICET), Buenos Aires, Argentina, Cátedra de Química Medicinal, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
⨯

G2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone Compound

Maia Cabrera,
Natalia Gomez,
Federico Remes Lenicov,
Emiliana Echeverría,
Carina Shayo,
Albertina Moglioni,
Natalia Fernández,
Carlos Davio

Published: September 11, 2015
https://doi.org/10.1371/journal.pone.0136878

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Cyclins
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Cell cycle and cell division
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