Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice

Daniel A. Briere; Xiaoping Ruan; Christine C. Cheng; Angela M. Siesky; Thomas E. Fitch; Carmen Dominguez; Sonia Gutierrez Sanfeliciano; Carlos Montero; Chen S. Suen; Yanping Xu; Tamer Coskun; M. Dodson Michael

doi:10.1371/journal.pone.0136873

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Open Access

Peer-reviewed

Research Article

Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice

Daniel A. Briere,

Affiliation Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America
⨯
Xiaoping Ruan,

Affiliation Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America
⨯
Christine C. Cheng,

Affiliation Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America
⨯
Angela M. Siesky,

Affiliation Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America
⨯
Thomas E. Fitch,

Affiliation Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America
⨯
Carmen Dominguez,

Affiliation Centro de Investigación, Eli Lilly and Company, Alcobendas, Spain
⨯
Sonia Gutierrez Sanfeliciano,

Affiliation Centro de Investigación, Eli Lilly and Company, Alcobendas, Spain
⨯
Carlos Montero,

Affiliation Centro de Investigación, Eli Lilly and Company, Alcobendas, Spain
⨯
Chen S. Suen,

Current address: National Cancer Institute, Bethesda, Maryland, United States of America

Affiliation Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America
⨯
Yanping Xu,

Affiliation Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America
⨯
Tamer Coskun,

Affiliation Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America
⨯
M. Dodson Michael

* E-mail: dod.michael@lilly.com

Affiliation Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, Indiana, United States of America
⨯

Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice

Daniel A. Briere,
Xiaoping Ruan,
Christine C. Cheng,
Angela M. Siesky,
Thomas E. Fitch,
Carmen Dominguez,
Sonia Gutierrez Sanfeliciano,
Carlos Montero,
Chen S. Suen,
Yanping Xu

Published: August 27, 2015
https://doi.org/10.1371/journal.pone.0136873

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