A Novel Prime and Boost Regimen of HIV Virus-Like Particles with TLR4 Adjuvant MPLA Induces Th1 Oriented Immune Responses against HIV

Ethan Poteet; Phoebe Lewis; Feng Li; Sheng Zhang; Jianhua Gu; Changyi Chen; Sam On Ho; Thai Do; SuMing Chiang; Gary Fujii; Qizhi Yao

doi:10.1371/journal.pone.0136862

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Open Access

Peer-reviewed

Research Article

A Novel Prime and Boost Regimen of HIV Virus-Like Particles with TLR4 Adjuvant MPLA Induces Th1 Oriented Immune Responses against HIV

Ethan Poteet,

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX, 77030, United States of America
⨯
Phoebe Lewis,

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX, 77030, United States of America
⨯
Feng Li,

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX, 77030, United States of America
⨯
Sheng Zhang,

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX, 77030, United States of America
⨯
Jianhua Gu,

Affiliation Houston Methodist Research Institute, Houston, TX, 77030, United States of America
⨯
Changyi Chen,

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX, 77030, United States of America
⨯
Sam On Ho,

Affiliation Molecular Express, Inc., Rancho Domínguez, CA, 90220, United States of America
⨯
Thai Do,

Affiliation Molecular Express, Inc., Rancho Domínguez, CA, 90220, United States of America
⨯
SuMing Chiang,

Affiliation Molecular Express, Inc., Rancho Domínguez, CA, 90220, United States of America
⨯
Gary Fujii,

Affiliation Molecular Express, Inc., Rancho Domínguez, CA, 90220, United States of America
⨯
Qizhi Yao

* E-mail: qizhiyao@bcm.edu

Affiliations Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, TX, 77030, United States of America, Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, TX, 77030, United States of America
⨯

A Novel Prime and Boost Regimen of HIV Virus-Like Particles with TLR4 Adjuvant MPLA Induces Th1 Oriented Immune Responses against HIV

Ethan Poteet,
Phoebe Lewis,
Feng Li,
Sheng Zhang,
Jianhua Gu,
Changyi Chen,
Sam On Ho,
Thai Do,
SuMing Chiang,
Gary Fujii

Published: August 27, 2015
https://doi.org/10.1371/journal.pone.0136862

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