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Open Access
Peer-reviewed
Research Article
Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes
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Priscilla F. McAuliffe ,
Contributed equally to this work with: Priscilla F. McAuliffe, Kurt W. Evans
Current address: Department of Surgical Oncology, The University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America
Affiliation Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Kurt W. Evans ,
Contributed equally to this work with: Priscilla F. McAuliffe, Kurt W. Evans
Affiliation Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Argun Akcakanat,
Affiliation Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Ken Chen,
Affiliation Department of Bioinformatics and Computational Science, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Xiaofeng Zheng,
Affiliation Department of Bioinformatics and Computational Science, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Hao Zhao,
Affiliation Department of Bioinformatics and Computational Science, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Agda Karina Eterovic,
Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Takafumi Sangai,
Current address: Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
Affiliation Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Ashley M. Holder,
Current address: Department of Surgery, Washington University in St. Louis, St. Louis, MO, United States of America
Affiliation Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Chandeshwar Sharma,
Current address: Department of Biology, Houston Community College Coleman College for Health Sciences, Houston, TX, United States of America
Affiliation Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Huiqin Chen,
Affiliation Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Kim-Anh Do,
Affiliation Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Emily Tarco,
Affiliation Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Mihai Gagea,
Affiliation Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Katherine A. Naff,
Affiliation Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Aysegul Sahin,
Affiliation Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Asha S. Multani,
Affiliation Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Dalliah M. Black,
Affiliation Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Elizabeth A. Mittendorf,
Affiliation Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Isabelle Bedrosian,
Affiliation Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Gordon B. Mills,
Affiliation Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Ana Maria Gonzalez-Angulo,
Affiliation Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Funda Meric-Bernstam
* E-mail: fmeric@mdanderson.org
Affiliations Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America, Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America
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Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes
- Priscilla F. McAuliffe,
- Kurt W. Evans,
- Argun Akcakanat,
- Ken Chen,
- Xiaofeng Zheng,
- Hao Zhao,
- Agda Karina Eterovic,
- Takafumi Sangai,
- Ashley M. Holder,
- Chandeshwar Sharma
- Published: September 1, 2015
- https://doi.org/10.1371/journal.pone.0136851