Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

Tommy Pacana; Sophie Cazanave; Aurora Verdianelli; Vaishali Patel; Hae-Ki Min; Faridoddin Mirshahi; Eoin Quinlivan; Arun J. Sanyal

doi:10.1371/journal.pone.0136822

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Peer-reviewed

Research Article

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

Tommy Pacana ,

* E-mail: asanyal@mcvh-vcu.edu (AJS); tpacana@mcvh-vcu.edu (TP)

Affiliation Div. of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, United States of America
⨯
Sophie Cazanave,

Affiliation Div. of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, United States of America
⨯
Aurora Verdianelli,

Affiliation Div. of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, United States of America
⨯
Vaishali Patel,

Affiliation Div. of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, United States of America
⨯
Hae-Ki Min,

Affiliation Div. of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, United States of America
⨯
Faridoddin Mirshahi,

Affiliation Div. of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, United States of America
⨯
Eoin Quinlivan,

Affiliation Biomedical Mass Spectrometry Laboratory, General Clinical Research Center, University of Florida, Gainesville, FL, United States of America
⨯
Arun J. Sanyal

* E-mail: asanyal@mcvh-vcu.edu (AJS); tpacana@mcvh-vcu.edu (TP)

Affiliation Div. of Gastroenterology, Hepatology and Nutrition, Dept. of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, United States of America
⨯

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease

Tommy Pacana,
Sophie Cazanave,
Aurora Verdianelli,
Vaishali Patel,
Hae-Ki Min,
Faridoddin Mirshahi,
Eoin Quinlivan,
Arun J. Sanyal

Published: August 31, 2015
https://doi.org/10.1371/journal.pone.0136822

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Methionine
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Diet
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DNA methylation
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Glutathione
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Fatty liver
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Methyltransferases
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Serine
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