A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media

Open Access

Peer-reviewed

Research Article

Julien Robitaille,

Affiliation Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, C.P. 6079, Centre-ville Station, Montreal (Quebec), Canada
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Jingkui Chen,

Affiliation Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, C.P. 6079, Centre-ville Station, Montreal (Quebec), Canada
⨯
Mario Jolicoeur

* E-mail: mario.jolicoeur@polymtl.ca

Affiliation Research Laboratory in Applied Metabolic Engineering, Department of Chemical Engineering, École Polytechnique de Montréal, C.P. 6079, Centre-ville Station, Montreal (Quebec), Canada
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Cell metabolism
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Glutamine
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Batch culture
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CHO cells
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Ammonia
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Citric acid cycle
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Glycolysis
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Culture media
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