Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy

Rebecca Gilbert; Richard M. Martin; David M. Evans; Kate Tilling; George Davey Smith; John P. Kemp; J. Athene Lane; Freddie C. Hamdy; David E. Neal; Jenny L. Donovan; Chris Metcalfe

doi:10.1371/journal.pone.0136735

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Open Access

Peer-reviewed

Research Article

Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy

Rebecca Gilbert ,

* E-mail: Becky.Gilbert@bristol.ac.uk

Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
Richard M. Martin,

Affiliations School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
⨯
David M. Evans,

Affiliations School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
⨯
Kate Tilling,

Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
George Davey Smith,

Affiliations School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
⨯
John P. Kemp,

Affiliations School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom, University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia
⨯
J. Athene Lane,

Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
Freddie C. Hamdy,

Affiliation Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom
⨯
David E. Neal,

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom
⨯
Jenny L. Donovan,

Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
Chris Metcalfe

Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯

Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy

Rebecca Gilbert,
Richard M. Martin,
David M. Evans,
Kate Tilling,
George Davey Smith,
John P. Kemp,
J. Athene Lane,
Freddie C. Hamdy,
David E. Neal,
Jenny L. Donovan

Published: October 2, 2015
https://doi.org/10.1371/journal.pone.0136735

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Human genetics
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Biopsy
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Single nucleotide polymorphisms
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