Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance

Sung Hyun Ahn; Doo Hyun Kim; Ah Ram Lee; Beom Kyung Kim; Yong Kwang Park; Eun-Sook Park; Sang Hoon Ahn; Gu-Choul Shin; Soree Park; Hong Seok Kang; Jin-Kyu Rhee; Sung-Il Yang; Youhoon Chong; Kyun-Hwan Kim

doi:10.1371/journal.pone.0136728

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Open Access

Peer-reviewed

Research Article

Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance

Sung Hyun Ahn ,

Contributed equally to this work with: Sung Hyun Ahn, Doo Hyun Kim, Ah Ram Lee

Affiliation Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea
⨯
Doo Hyun Kim ,

Contributed equally to this work with: Sung Hyun Ahn, Doo Hyun Kim, Ah Ram Lee

Affiliation Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea
⨯
Ah Ram Lee ,

Contributed equally to this work with: Sung Hyun Ahn, Doo Hyun Kim, Ah Ram Lee

Affiliation Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea
⨯
Beom Kyung Kim,

Affiliation Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
⨯
Yong Kwang Park,

Affiliation Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea
⨯
Eun-Sook Park,

Affiliations Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea, KU Open Innovation Center, Konkuk University, Seoul, Korea
⨯
Sang Hoon Ahn,

Affiliation Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
⨯
Gu-Choul Shin,

Affiliations Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea, KU Open Innovation Center, Konkuk University, Seoul, Korea
⨯
Soree Park,

Affiliation Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea
⨯
Hong Seok Kang,

Affiliation Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea
⨯
Jin-Kyu Rhee,

Affiliation Departments of Food Science and Engineering, Ewha Womans University, Seoul, Korea
⨯
Sung-Il Yang,

Affiliation Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea
⨯
Youhoon Chong,

Affiliation Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea
⨯
Kyun-Hwan Kim

* E-mail: khkim10@kku.ac.kr

Affiliations Department of Pharmacology, Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea, KU Open Innovation Center, Konkuk University, Seoul, Korea, Research Institute of Medical Sciences, Konkuk University, Seoul, Korea
⨯

Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance

Sung Hyun Ahn,
Doo Hyun Kim,
Ah Ram Lee,
Beom Kyung Kim,
Yong Kwang Park,
Eun-Sook Park,
Sang Hoon Ahn,
Gu-Choul Shin,
Soree Park,
Hong Seok Kang

Published: August 31, 2015
https://doi.org/10.1371/journal.pone.0136728

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Substitution mutation
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Hepatitis B virus
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