Decreased 11β-Hydroxysteroid Dehydrogenase 1 Level and Activity in Murine Pancreatic Islets Caused by Insulin-Like Growth Factor I Overexpression

Subrata Chowdhury; Larson Grimm; Ying Jia Kate Gong; Beixi Wang; Bing Li; Coimbatore B. Srikant; Zu-hua Gao; Jun-Li Liu

doi:10.1371/journal.pone.0136656

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Open Access

Peer-reviewed

Research Article

Decreased 11β-Hydroxysteroid Dehydrogenase 1 Level and Activity in Murine Pancreatic Islets Caused by Insulin-Like Growth Factor I Overexpression

Subrata Chowdhury,

Affiliation Fraser Laboratories for Diabetes Research, Department of Medicine, the Research Institute of McGill University Health Centre, Montreal, Canada
⨯
Larson Grimm,

Affiliation Fraser Laboratories for Diabetes Research, Department of Medicine, the Research Institute of McGill University Health Centre, Montreal, Canada
⨯
Ying Jia Kate Gong,

Affiliation Fraser Laboratories for Diabetes Research, Department of Medicine, the Research Institute of McGill University Health Centre, Montreal, Canada
⨯
Beixi Wang,

Affiliation Fraser Laboratories for Diabetes Research, Department of Medicine, the Research Institute of McGill University Health Centre, Montreal, Canada
⨯
Bing Li,

Affiliation Fraser Laboratories for Diabetes Research, Department of Medicine, the Research Institute of McGill University Health Centre, Montreal, Canada
⨯
Coimbatore B. Srikant,

Affiliation Fraser Laboratories for Diabetes Research, Department of Medicine, the Research Institute of McGill University Health Centre, Montreal, Canada
⨯
Zu-hua Gao ,

* E-mail: jun-li.liu@mcgill.ca (JLL); zu-hua.gao@mcgill.ca (ZHG)

Affiliation Department of Pathology, the Research Institute of McGill University Health Centre, Montreal, Canada
⨯
Jun-Li Liu

* E-mail: jun-li.liu@mcgill.ca (JLL); zu-hua.gao@mcgill.ca (ZHG)

Affiliations Fraser Laboratories for Diabetes Research, Department of Medicine, the Research Institute of McGill University Health Centre, Montreal, Canada, Montreal Diabetes Research Centre, Montreal, Canada
⨯

Decreased 11β-Hydroxysteroid Dehydrogenase 1 Level and Activity in Murine Pancreatic Islets Caused by Insulin-Like Growth Factor I Overexpression

Subrata Chowdhury,
Larson Grimm,
Ying Jia Kate Gong,
Beixi Wang,
Bing Li,
Coimbatore B. Srikant,
Zu-hua Gao,
Jun-Li Liu

Published: August 25, 2015
https://doi.org/10.1371/journal.pone.0136656

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