Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease

Kazuyuki Kitatani; Masayuki Wada; David Perry; Toshinori Usui; Ying Sun; Lina M. Obeid; Nobuo Yaegashi; Gregory A. Grabowski; Yusuf A. Hannun

doi:10.1371/journal.pone.0136633

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Open Access

Peer-reviewed

Research Article

Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease

Kazuyuki Kitatani ,

* E-mail: kitatani@med.tohoku.ac.jp (KK); yusuf.hannun@sbumed.org (YAH)

Affiliations Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan, Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Masayuki Wada,

Affiliation Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, United States of America
⨯
David Perry,

Affiliation Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Toshinori Usui,

Affiliation Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
⨯
Ying Sun,

Affiliations Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Departments of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Lina M. Obeid,

Affiliations Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, United States of America, Northport Veterans Affairs Hospital, Northport, New York, United States of America, Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America
⨯
Nobuo Yaegashi,

Affiliations Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan, Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Gregory A. Grabowski,

Affiliations Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America, Departments of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Yusuf A. Hannun

* E-mail: kitatani@med.tohoku.ac.jp (KK); yusuf.hannun@sbumed.org (YAH)

Affiliations Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, United States of America, Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America
⨯

Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease

Kazuyuki Kitatani,
Masayuki Wada,
David Perry,
Toshinori Usui,
Ying Sun,
Lina M. Obeid,
Nobuo Yaegashi,
Gregory A. Grabowski,
Yusuf A. Hannun

Published: August 27, 2015
https://doi.org/10.1371/journal.pone.0136633

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