Decline of Phosphotransfer and Substrate Supply Metabolic Circuits Hinders ATP Cycling in Aging Myocardium

Emirhan Nemutlu; Anu Gupta; Song Zhang; Maria Viqar; Ekhson Holmuhamedov; Andre Terzic; Arshad Jahangir; Petras Dzeja

doi:10.1371/journal.pone.0136556

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Peer-reviewed

Research Article

Decline of Phosphotransfer and Substrate Supply Metabolic Circuits Hinders ATP Cycling in Aging Myocardium

Emirhan Nemutlu,

Current address: Department of Analytical Chemistry, Faculty of Pharmacy, University of Hacettepe, 06100 Ankara, Turkey

Affiliation Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Anu Gupta,

Affiliation Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Song Zhang,

Affiliation Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Maria Viqar,

Affiliation Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Ekhson Holmuhamedov,

Affiliation Center for Integrative Research on Cardiovascular Aging (CIRCA), Aurora University of Wisconsin Medical Group, Aurora Health Care, Milwaukee, Wisconsin, United States of America
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Andre Terzic,

Affiliation Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
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Arshad Jahangir ,

* E-mail: dzeja.petras@mayo.edu (PD); arshad.jahangir@aurora.org (AJ)

Affiliation Center for Integrative Research on Cardiovascular Aging (CIRCA), Aurora University of Wisconsin Medical Group, Aurora Health Care, Milwaukee, Wisconsin, United States of America
⨯
Petras Dzeja

* E-mail: dzeja.petras@mayo.edu (PD); arshad.jahangir@aurora.org (AJ)

Affiliation Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Decline of Phosphotransfer and Substrate Supply Metabolic Circuits Hinders ATP Cycling in Aging Myocardium

Emirhan Nemutlu,
Anu Gupta,
Song Zhang,
Maria Viqar,
Ekhson Holmuhamedov,
Andre Terzic,
Arshad Jahangir,
Petras Dzeja

Published: September 17, 2015
https://doi.org/10.1371/journal.pone.0136556

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Myocardium
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Mitochondria
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Bioenergetics
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Adenosine triphosphatase
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Phosphates
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Enzyme metabolism
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Cardiac atria
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Creatine
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