Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes

Jiqian Xu; Houxiang Hu; Bin Chen; Rongchuan Yue; Zhou Zhou; Yin Liu; Shuang Zhang; Lei Xu; Huan Wang; Zhengping Yu

doi:10.1371/journal.pone.0136443

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Peer-reviewed

Research Article

Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes

Jiqian Xu,

Affiliations Department of Cardiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, Sichuan, China, Department of Anesthesiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, Sichuan, China
⨯
Houxiang Hu ,

* E-mail: hhxiang17@163.com (HH); chenbin8703@163.com (BC)

Affiliation Department of Cardiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, Sichuan, China
⨯
Bin Chen ,

* E-mail: hhxiang17@163.com (HH); chenbin8703@163.com (BC)

Affiliation Department of Anesthesiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, Sichuan, China
⨯
Rongchuan Yue,

Affiliation Department of Cardiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, Sichuan, China
⨯
Zhou Zhou,

Affiliation Department of Occupational Health, Third Military Medical University, Chongqing 400038, China
⨯
Yin Liu,

Affiliation Department of physiology and pharmacology, Western University, London, Ontario, N6A 5C1, Canada
⨯
Shuang Zhang,

Affiliation Department of Cardiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, Sichuan, China
⨯
Lei Xu,

Affiliation Department of Cardiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, Sichuan, China
⨯
Huan Wang,

Affiliation Department of Cardiology, North Sichuan Medical College Affiliated Hospital, Nanchong 637000, Sichuan, China
⨯
Zhengping Yu

Affiliation Department of Occupational Health, Third Military Medical University, Chongqing 400038, China
⨯

Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes

Jiqian Xu,
Houxiang Hu,
Bin Chen,
Rongchuan Yue,
Zhou Zhou,
Yin Liu,
Shuang Zhang,
Lei Xu,
Huan Wang,
Zhengping Yu

Published: August 20, 2015
https://doi.org/10.1371/journal.pone.0136443

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Cardiomyocytes
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Apoptosis
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Endoplasmic reticulum
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Gene expression
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Hypoxia
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Phosphorylation
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Scanning confocal microscopy
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Protein expression
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