Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a “Painless” Lead Investigational Candidate for Therapeutic Applications

Francesca Malerba; Francesca Paoletti; Bruno Bruni Ercole; Serena Materazzi; Romina Nassini; Elisabetta Coppi; Riccardo Patacchini; Simona Capsoni; Doriano Lamba; Antonino Cattaneo

doi:10.1371/journal.pone.0136425

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Peer-reviewed

Research Article

Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a “Painless” Lead Investigational Candidate for Therapeutic Applications

Francesca Malerba ,

Contributed equally to this work with: Francesca Malerba, Francesca Paoletti

Affiliations Neurotrophic Factors and Neurodegenerative Diseases Unit, European Brain Research Institute, “Rita Levi-Montalcini” Foundation, Rome, Italy, Neurobiology Laboratory of Biology, Scuola Normale Superiore, Pisa, Italy
⨯
Francesca Paoletti ,

Contributed equally to this work with: Francesca Malerba, Francesca Paoletti

Affiliations Neurotrophic Factors and Neurodegenerative Diseases Unit, European Brain Research Institute, “Rita Levi-Montalcini” Foundation, Rome, Italy, Neurobiology Laboratory of Biology, Scuola Normale Superiore, Pisa, Italy
⨯
Bruno Bruni Ercole,

Affiliation Neurotrophic Factors and Neurodegenerative Diseases Unit, European Brain Research Institute, “Rita Levi-Montalcini” Foundation, Rome, Italy
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Serena Materazzi,

Affiliation Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy
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Romina Nassini,

Affiliation Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy
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Elisabetta Coppi,

Affiliation Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy
⨯
Riccardo Patacchini,

Affiliation Department of Pharmacology, Chiesi Farmaceutici, Parma, Italy
⨯
Simona Capsoni,

Affiliation Neurobiology Laboratory of Biology, Scuola Normale Superiore, Pisa, Italy
⨯
Doriano Lamba,

Affiliation Istituto di Cristallografia, Consiglio Nazionale delle Ricerche, Area Science Park–Basovizza, Trieste, Italy
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Antonino Cattaneo

* E-mail: antonino.cattaneo@sns.it

Affiliations Neurotrophic Factors and Neurodegenerative Diseases Unit, European Brain Research Institute, “Rita Levi-Montalcini” Foundation, Rome, Italy, Neurobiology Laboratory of Biology, Scuola Normale Superiore, Pisa, Italy
⨯

Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a “Painless” Lead Investigational Candidate for Therapeutic Applications

Francesca Malerba,
Francesca Paoletti,
Bruno Bruni Ercole,
Serena Materazzi,
Romina Nassini,
Elisabetta Coppi,
Riccardo Patacchini,
Simona Capsoni,
Doriano Lamba,
Antonino Cattaneo

Published: September 15, 2015
https://doi.org/10.1371/journal.pone.0136425

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