The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity

Mika Yasui; Yukinori Tamura; Manabu Minami; Sei Higuchi; Risako Fujikawa; Taichi Ikedo; Manabu Nagata; Hidenori Arai; Toshinori Murayama; Masayuki Yokode

doi:10.1371/journal.pone.0136304

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Open Access

Peer-reviewed

Research Article

The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity

Mika Yasui,

Affiliation Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
⨯
Yukinori Tamura,

Affiliations Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan, Department of Physiology and Regenerative Medicine, Kinki University Faculty of Medicine, Osakasayama, Osaka, Japan
⨯
Manabu Minami ,

* E-mail: mminami@kuhp.kyoto-u.ac.jp

Affiliation Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
⨯
Sei Higuchi,

Affiliation Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
⨯
Risako Fujikawa,

Affiliation Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
⨯
Taichi Ikedo,

Affiliations Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan, Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
⨯
Manabu Nagata,

Affiliations Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan, Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
⨯
Hidenori Arai,

Affiliation National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
⨯
Toshinori Murayama,

Affiliation Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
⨯
Masayuki Yokode

Affiliation Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
⨯

The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity

Mika Yasui,
Yukinori Tamura,
Manabu Minami,
Sei Higuchi,
Risako Fujikawa,
Taichi Ikedo,
Manabu Nagata,
Hidenori Arai,
Toshinori Murayama,
Masayuki Yokode

Published: August 26, 2015
https://doi.org/10.1371/journal.pone.0136304

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