Multiplex-PCR-Based Screening and Computational Modeling of Virulence Factors and T-Cell Mediated Immunity in Helicobacter pylori Infections for Accurate Clinical Diagnosis

Sinem Oktem-Okullu; Arzu Tiftikci; Murat Saruc; Bahattin Cicek; Eser Vardareli; Nurdan Tozun; Tanil Kocagoz; Ugur Sezerman; Ahmet Sinan Yavuz; Ayca Sayi-Yazgan

doi:10.1371/journal.pone.0136212

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Open Access

Peer-reviewed

Research Article

Multiplex-PCR-Based Screening and Computational Modeling of Virulence Factors and T-Cell Mediated Immunity in Helicobacter pylori Infections for Accurate Clinical Diagnosis

Sinem Oktem-Okullu,

Affiliations Department of Molecular Biology and Genetics, Istanbul Technical University, Maslak, Istanbul, Turkey, Department of Medical Microbiology, School of Medicine, Acibadem University, Atasehir, Istanbul, Turkey
⨯
Arzu Tiftikci,

Affiliations Department of Internal Medicine, School of Medicine, Acibadem University, Atasehir, Istanbul, Turkey, Department of Gastroenterology, Acibadem Hospital Group, Istanbul, Turkey
⨯
Murat Saruc,

Affiliations Department of Internal Medicine, School of Medicine, Acibadem University, Atasehir, Istanbul, Turkey, Department of Gastroenterology, Acibadem Hospital Group, Istanbul, Turkey
⨯
Bahattin Cicek,

Affiliations Department of Internal Medicine, School of Medicine, Acibadem University, Atasehir, Istanbul, Turkey, Department of Gastroenterology, Acibadem Hospital Group, Istanbul, Turkey
⨯
Eser Vardareli,

Affiliations Department of Internal Medicine, School of Medicine, Acibadem University, Atasehir, Istanbul, Turkey, Department of Gastroenterology, Acibadem Hospital Group, Istanbul, Turkey
⨯
Nurdan Tozun,

Affiliations Department of Internal Medicine, School of Medicine, Acibadem University, Atasehir, Istanbul, Turkey, Department of Gastroenterology, Acibadem Hospital Group, Istanbul, Turkey
⨯
Tanil Kocagoz,

Affiliation Department of Medical Microbiology, School of Medicine, Acibadem University, Atasehir, Istanbul, Turkey
⨯
Ugur Sezerman,

Affiliation Department of Biostatistics and Medical Informatics, School of Medicine, Acibadem University, Atasehir, Istanbul, Turkey
⨯
Ahmet Sinan Yavuz,

Affiliation Molecular Biology, Genetics and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabancı University, Tuzla, Istanbul, Turkey
⨯
Ayca Sayi-Yazgan

* E-mail: sayi@itu.edu.tr

Affiliation Department of Molecular Biology and Genetics, Istanbul Technical University, Maslak, Istanbul, Turkey
⨯

Multiplex-PCR-Based Screening and Computational Modeling of Virulence Factors and T-Cell Mediated Immunity in Helicobacter pylori Infections for Accurate Clinical Diagnosis

Sinem Oktem-Okullu,
Arzu Tiftikci,
Murat Saruc,
Bahattin Cicek,
Eser Vardareli,
Nurdan Tozun,
Tanil Kocagoz,
Ugur Sezerman,
Ahmet Sinan Yavuz,
Ayca Sayi-Yazgan

Published: August 19, 2015
https://doi.org/10.1371/journal.pone.0136212

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Helicobacter pylori
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Virulence factors
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Ulcers
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Urea
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Immune response
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Polymerase chain reaction
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Gene expression
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