Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation

Aimen O. Amer; Philip M. Probert; Michael Dunn; Margaret Knight; Abigail E. Vallance; Paul A. Flecknell; Fiona Oakley; Iain Cameron; Steven A. White; Peter G. Blain; Matthew C. Wright

doi:10.1371/journal.pone.0136173

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Open Access

Peer-reviewed

Research Article

Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation

Aimen O. Amer,

Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom
⨯
Philip M. Probert,

Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom
⨯
Michael Dunn,

Affiliations Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom, Medical Toxicology Centre, Newcastle University, Newcastle, United Kingdom
⨯
Margaret Knight,

Affiliations Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom, Medical Toxicology Centre, Newcastle University, Newcastle, United Kingdom
⨯
Abigail E. Vallance,

Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom
⨯
Paul A. Flecknell,

Affiliation Comparative Biology Centre, Newcastle University, Newcastle, United Kingdom
⨯
Fiona Oakley,

Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom
⨯
Iain Cameron,

Affiliations Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom, Department of Pathology, Altnagelvin Hospital, Londonderry, United Kingdom
⨯
Steven A. White,

Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom
⨯
Peter G. Blain,

Affiliations Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom, Medical Toxicology Centre, Newcastle University, Newcastle, United Kingdom
⨯
Matthew C. Wright

* E-mail: M.C.Wright@ncl.ac.uk

Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom
⨯

Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation

Aimen O. Amer,
Philip M. Probert,
Michael Dunn,
Margaret Knight,
Abigail E. Vallance,
Paul A. Flecknell,
Fiona Oakley,
Iain Cameron,
Steven A. White,
Peter G. Blain

Published: August 24, 2015
https://doi.org/10.1371/journal.pone.0136173

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