Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma

Serena Cecchetti; Ileana Bortolomai; Renata Ferri; Laura Mercurio; Silvana Canevari; Franca Podo; Silvia Miotti; Egidio Iorio

doi:10.1371/journal.pone.0136120

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Research Article

Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma

Serena Cecchetti ,

Contributed equally to this work with: Serena Cecchetti, Ileana Bortolomai

Affiliation Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy
⨯
Ileana Bortolomai ,

Contributed equally to this work with: Serena Cecchetti, Ileana Bortolomai

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Renata Ferri,

Current address: Department of Experimental Oncology and Molecular Medicine, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Laura Mercurio,

Affiliation Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy
⨯
Silvana Canevari ,

* E-mail: franca.podo@alice.it (FP); silvana.canevari@istitutotumori.mi.it (SC)

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Franca Podo ,

* E-mail: franca.podo@alice.it (FP); silvana.canevari@istitutotumori.mi.it (SC)

Affiliation Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy
⨯
Silvia Miotti ,

Current address: Department of Experimental Oncology and Molecular Medicine, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

¶‡ These authors also contributed equally to this work.

Affiliation Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
⨯
Egidio Iorio

¶‡ These authors also contributed equally to this work.

Affiliation Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy
⨯

Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma

Serena Cecchetti,
Ileana Bortolomai,
Renata Ferri,
Laura Mercurio,
Silvana Canevari,
Franca Podo,
Silvia Miotti,
Egidio Iorio

Published: September 24, 2015
https://doi.org/10.1371/journal.pone.0136120

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