Depletion of the SR-Related Protein TbRRM1 Leads to Cell Cycle Arrest and Apoptosis-Like Death in Trypanosoma brucei

Gabriela V. Levy; Carolina P. Bañuelos; Analía G. Níttolo; Gastón E. Ortiz; Nicolás Mendiondo; Georgina Moretti; Valeria S. Tekiel; Daniel O. Sánchez

doi:10.1371/journal.pone.0136070

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Research Article

Depletion of the SR-Related Protein TbRRM1 Leads to Cell Cycle Arrest and Apoptosis-Like Death in Trypanosoma brucei

Gabriela V. Levy ,

* E-mail: gvlevy@gmail.com

Affiliation Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia. Gral. San Martín, Buenos Aires, Argentina
⨯
Carolina P. Bañuelos ,

Contributed equally to this work with: Carolina P. Bañuelos, Analía G. Níttolo, Gastón E. Ortiz, Nicolás Mendiondo

Affiliation Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia. Gral. San Martín, Buenos Aires, Argentina
⨯
Analía G. Níttolo ,

Contributed equally to this work with: Carolina P. Bañuelos, Analía G. Níttolo, Gastón E. Ortiz, Nicolás Mendiondo

Affiliation Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia. Gral. San Martín, Buenos Aires, Argentina
⨯
Gastón E. Ortiz ,

Contributed equally to this work with: Carolina P. Bañuelos, Analía G. Níttolo, Gastón E. Ortiz, Nicolás Mendiondo

Affiliation Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia. Gral. San Martín, Buenos Aires, Argentina
⨯
Nicolás Mendiondo ,

Contributed equally to this work with: Carolina P. Bañuelos, Analía G. Níttolo, Gastón E. Ortiz, Nicolás Mendiondo

Current address: Instituto de Microbiología y Parasitología Médica (IMPAM, UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires (UBA)—CONICET, Paraguay, CABA, Argentina

Affiliation Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia. Gral. San Martín, Buenos Aires, Argentina
⨯
Georgina Moretti,

Affiliation Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia. Gral. San Martín, Buenos Aires, Argentina
⨯
Valeria S. Tekiel,

Affiliation Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia. Gral. San Martín, Buenos Aires, Argentina
⨯
Daniel O. Sánchez

Affiliation Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martín (IIB-UNSAM)—Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 25 de Mayo y Francia. Gral. San Martín, Buenos Aires, Argentina
⨯

Depletion of the SR-Related Protein TbRRM1 Leads to Cell Cycle Arrest and Apoptosis-Like Death in Trypanosoma brucei

Gabriela V. Levy,
Carolina P. Bañuelos,
Analía G. Níttolo,
Gastón E. Ortiz,
Nicolás Mendiondo,
Georgina Moretti,
Valeria S. Tekiel,
Daniel O. Sánchez

Published: August 18, 2015
https://doi.org/10.1371/journal.pone.0136070

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Apoptosis
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Parasitic cell cycles
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RNA interference
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Trypanosoma
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Cell staining
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Trypanosoma brucei gambiense
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Messenger RNA
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Mitochondrial membrane
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