Active Immunization with Extracellular Vesicles Derived from Staphylococcus aureus Effectively Protects against Staphylococcal Lung Infections, Mainly via Th1 Cell-Mediated Immunity

Seng Jin Choi; Min-Hye Kim; Jinseong Jeon; Oh Youn Kim; Youngwoo Choi; Jihye Seo; Sung-Wook Hong; Won-Hee Lee; Seong Gyu Jeon; Yong Song Gho; Young-Koo Jee; Yoon-Keun Kim

doi:10.1371/journal.pone.0136021

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Open Access

Peer-reviewed

Research Article

Active Immunization with Extracellular Vesicles Derived from Staphylococcus aureus Effectively Protects against Staphylococcal Lung Infections, Mainly via Th1 Cell-Mediated Immunity

Seng Jin Choi,

Affiliation Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
⨯
Min-Hye Kim,

Affiliation Department of Medicine, Ewha Womans University School of Medicine and Ewha Institute of Convergence Medicine, Ewha Womans Medical Center, Seoul, Republic of Korea
⨯
Jinseong Jeon,

Affiliation Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
⨯
Oh Youn Kim,

Affiliation Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
⨯
Youngwoo Choi,

Affiliation Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
⨯
Jihye Seo,

Affiliation Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
⨯
Sung-Wook Hong,

Affiliations Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS), Pohang, Republic of Korea, Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
⨯
Won-Hee Lee,

Affiliation Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
⨯
Seong Gyu Jeon ,

* E-mail: juinea@ewha.ac.kr (YK); gene49@hanmail.net (SJ)

Affiliation Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
⨯
Yong Song Gho,

Affiliation Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
⨯
Young-Koo Jee,

Affiliation Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea
⨯
Yoon-Keun Kim

* E-mail: juinea@ewha.ac.kr (YK); gene49@hanmail.net (SJ)

Affiliation Department of Medicine, Ewha Womans University School of Medicine and Ewha Institute of Convergence Medicine, Ewha Womans Medical Center, Seoul, Republic of Korea
⨯

Active Immunization with Extracellular Vesicles Derived from Staphylococcus aureus Effectively Protects against Staphylococcal Lung Infections, Mainly via Th1 Cell-Mediated Immunity

Seng Jin Choi,
Min-Hye Kim,
Jinseong Jeon,
Oh Youn Kim,
Youngwoo Choi,
Jihye Seo,
Sung-Wook Hong,
Won-Hee Lee,
Seong Gyu Jeon,
Yong Song Gho

Published: September 2, 2015
https://doi.org/10.1371/journal.pone.0136021

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