Stereoselective Regulation of P-gp Activity by Clausenamide Enantiomers in Caco-2, KB/KBv and Brain Microvessel Endothelial Cells

• Chuan-jiang Zhu ,

  * E-mail: zhucj@imm.ac.cn

  Affiliations Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Beijing, China, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Beijing, China

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• Fang Hua,

  Affiliation Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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• Xiao-lu Zhu,

  Affiliation Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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• Meng Li,

  Affiliation Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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• Hong-xu Wang,

  Affiliation Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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• Xiao-ming Yu,

  Affiliations Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Beijing, China

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• Yan Li

  Affiliations Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD Study, Beijing, China

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