SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells

Pinar Obakan; Carlos Barrero; Ajda Coker-Gurkan; Elif Damla Arisan; Salim Merali; Narcin Palavan-Unsal

doi:10.1371/journal.pone.0135788

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Research Article

SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells

Pinar Obakan ,

Contributed equally to this work with: Pinar Obakan, Carlos Barrero, Ajda Coker-Gurkan, Elif Damla Arisan, Salim Merali, Narcin Palavan-Unsal

* E-mail: p.obakan@iku.edu.tr

Affiliation Istanbul Kultur University, Department of Molecular Biology and Genetics, Atakoy Campus, Bakirkoy, Istanbul-Turkey
⨯
Carlos Barrero ,

Contributed equally to this work with: Pinar Obakan, Carlos Barrero, Ajda Coker-Gurkan, Elif Damla Arisan, Salim Merali, Narcin Palavan-Unsal

Affiliation Department of Biochemistry, Temple University School of Medicine, Fels Institute, 3307 N. Broad Street, Philadelphia, Pennsylvania, United States of America
⨯
Ajda Coker-Gurkan ,

Contributed equally to this work with: Pinar Obakan, Carlos Barrero, Ajda Coker-Gurkan, Elif Damla Arisan, Salim Merali, Narcin Palavan-Unsal

Affiliation Istanbul Kultur University, Department of Molecular Biology and Genetics, Atakoy Campus, Bakirkoy, Istanbul-Turkey
⨯
Elif Damla Arisan ,

Contributed equally to this work with: Pinar Obakan, Carlos Barrero, Ajda Coker-Gurkan, Elif Damla Arisan, Salim Merali, Narcin Palavan-Unsal

Affiliation Istanbul Kultur University, Department of Molecular Biology and Genetics, Atakoy Campus, Bakirkoy, Istanbul-Turkey
⨯
Salim Merali ,

Contributed equally to this work with: Pinar Obakan, Carlos Barrero, Ajda Coker-Gurkan, Elif Damla Arisan, Salim Merali, Narcin Palavan-Unsal

Affiliation Department of Biochemistry, Temple University School of Medicine, Fels Institute, 3307 N. Broad Street, Philadelphia, Pennsylvania, United States of America
⨯
Narcin Palavan-Unsal

Contributed equally to this work with: Pinar Obakan, Carlos Barrero, Ajda Coker-Gurkan, Elif Damla Arisan, Salim Merali, Narcin Palavan-Unsal

Affiliation Istanbul Kultur University, Department of Molecular Biology and Genetics, Atakoy Campus, Bakirkoy, Istanbul-Turkey
⨯

SILAC-Based Mass Spectrometry Analysis Reveals That Epibrassinolide Induces Apoptosis via Activating Endoplasmic Reticulum Stress in Prostate Cancer Cells

Pinar Obakan,
Carlos Barrero,
Ajda Coker-Gurkan,
Elif Damla Arisan,
Salim Merali,
Narcin Palavan-Unsal

Published: September 9, 2015
https://doi.org/10.1371/journal.pone.0135788

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Apoptosis
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Prostate cancer
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Cancer treatment
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Stable isotope labeling by amino acids in cell culture
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Chaperone proteins
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Endoplasmic reticulum
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Heat shock response
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Transfection
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