Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer

Noah D. Peyser; Yu Du; Hua Li; Vivian Lui; Xiao Xiao; Timothy A. Chan; Jennifer R. Grandis

doi:10.1371/journal.pone.0135750

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Peer-reviewed

Research Article

Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer

Noah D. Peyser ,

Contributed equally to this work with: Noah D. Peyser, Yu Du

Affiliations Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, 15213, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, 15213
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Yu Du ,

Contributed equally to this work with: Noah D. Peyser, Yu Du

Affiliations Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, 15213, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, 15213, School of Medicine, Tsinghua University, Beijing, China, 100084
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Hua Li,

Affiliation Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, 15213
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Vivian Lui,

Affiliations Pharmacogenomics and Precision Therapeutics Laboratory, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China, Department of Biochemistry, The University of Hong Kong, Hong Kong SAR, China
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Xiao Xiao,

Affiliation Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America, 15213
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Timothy A. Chan,

Affiliation Human Oncology and Pathogenesis Program and Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, United States of America, 10065
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Jennifer R. Grandis

* E-mail: Jennifer.Grandis@ucsf.edu

Affiliation Department of Otolaryngology, University of California San Francisco, San Francisco, CA, United States of America, 94143
⨯

Loss-of-Function PTPRD Mutations Lead to Increased STAT3 Activation and Sensitivity to STAT3 Inhibition in Head and Neck Cancer

Noah D. Peyser,
Yu Du,
Hua Li,
Vivian Lui,
Xiao Xiao,
Timothy A. Chan,
Jennifer R. Grandis

Published: August 12, 2015
https://doi.org/10.1371/journal.pone.0135750

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Head and neck cancers
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Nonsense mutation
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