TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression

Zhijun Zhao; Xiaodong Hou; Xiaoxiang Yin; Yanyun Li; Rong Duan; Brendan F. Boyce; Zhenqiang Yao

doi:10.1371/journal.pone.0135728

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Research Article

TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression

Zhijun Zhao ,

Contributed equally to this work with: Zhijun Zhao, Xiaodong Hou

Affiliation Department of Medical Imaging, Henan University First Affiliated Hospital, 357 Ximen Street, Kaifeng, Henan 475001, P.R. China
⨯
Xiaodong Hou ,

Contributed equally to this work with: Zhijun Zhao, Xiaodong Hou

Affiliations Department of Medical Imaging, Henan University First Affiliated Hospital, 357 Ximen Street, Kaifeng, Henan 475001, P.R. China, University of Rochester Medical Center, Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, Box 626, Room 1–2105, 601 Elmwood Ave, Rochester, NY 14642, United States of America
⨯
Xiaoxiang Yin,

Affiliations Department of Medical Imaging, Henan University First Affiliated Hospital, 357 Ximen Street, Kaifeng, Henan 475001, P.R. China, University of Rochester Medical Center, Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, Box 626, Room 1–2105, 601 Elmwood Ave, Rochester, NY 14642, United States of America
⨯
Yanyun Li,

Affiliation University of Rochester Medical Center, Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, Box 626, Room 1–2105, 601 Elmwood Ave, Rochester, NY 14642, United States of America
⨯
Rong Duan,

Affiliation University of Rochester Medical Center, Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, Box 626, Room 1–2105, 601 Elmwood Ave, Rochester, NY 14642, United States of America
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Brendan F. Boyce,

Affiliation University of Rochester Medical Center, Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, Box 626, Room 1–2105, 601 Elmwood Ave, Rochester, NY 14642, United States of America
⨯
Zhenqiang Yao

* E-mail: zhenqiang_yao@urmc.rochester.edu

Affiliation University of Rochester Medical Center, Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, Box 626, Room 1–2105, 601 Elmwood Ave, Rochester, NY 14642, United States of America
⨯

TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression

Zhijun Zhao,
Xiaodong Hou,
Xiaoxiang Yin,
Yanyun Li,
Rong Duan,
Brendan F. Boyce,
Zhenqiang Yao

Published: August 19, 2015
https://doi.org/10.1371/journal.pone.0135728

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