Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge

Freek Cox; Anna Roos; Nicole Hafkemeijer; Matthijs Baart; Jeroen Tolboom; Liesbeth Dekking; Koert Stittelaar; Jaap Goudsmit; Katarina Radošević; Eirikur Saeland

doi:10.1371/journal.pone.0135723

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Open Access

Peer-reviewed

Research Article

Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge

Freek Cox ,

Contributed equally to this work with: Freek Cox, Anna Roos

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Anna Roos ,

Contributed equally to this work with: Freek Cox, Anna Roos

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Nicole Hafkemeijer,

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Matthijs Baart,

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Jeroen Tolboom,

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Liesbeth Dekking,

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Koert Stittelaar,

Affiliation Viroclinics Biosciences, Rotterdam, The Netherlands
⨯
Jaap Goudsmit,

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Katarina Radošević,

Current address: Sanofi, Global Biotherapeutics, Vitry-sur-Seine, France

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯
Eirikur Saeland

* E-mail: Esaeland@its.jnj.com

Current address: Infectious Diseases and Vaccines Therapeutic area, Janssen Research and Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands

Affiliation Janssen Prevention Center, Center of Excellence of Janssen Research & Development, Pharmaceutical companies of Johnson and Johnson, Leiden, The Netherlands
⨯

Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge

Freek Cox,
Anna Roos,
Nicole Hafkemeijer,
Matthijs Baart,
Jeroen Tolboom,
Liesbeth Dekking,
Koert Stittelaar,
Jaap Goudsmit,
Katarina Radošević,
Eirikur Saeland

Published: September 24, 2015
https://doi.org/10.1371/journal.pone.0135723

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