Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells

Ana Sofia Rodrigues; Sandro L. Pereira; Marcelo Correia; Andreia Gomes; Tânia Perestrelo; João Ramalho-Santos

doi:10.1371/journal.pone.0135617

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Peer-reviewed

Research Article

Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells

Ana Sofia Rodrigues,

Affiliations PhD Programme in Experimental Biology and Biomedicine, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
⨯
Sandro L. Pereira,

Affiliation CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
⨯
Marcelo Correia,

Affiliations PhD Programme in Experimental Biology and Biomedicine, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal
⨯
Andreia Gomes,

Affiliations PhD Programme in Experimental Biology and Biomedicine, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal, Biocant—Center of Innovation in Biotechnology, Cantanhede, Portugal
⨯
Tânia Perestrelo,

Affiliations PhD Programme in Experimental Biology and Biomedicine, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal
⨯
João Ramalho-Santos

* E-mail: jramalho@ci.uc.pt

Affiliations CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Department of Life Sciences, University of Coimbra, Coimbra, Portugal
⨯

Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells

Ana Sofia Rodrigues,
Sandro L. Pereira,
Marcelo Correia,
Andreia Gomes,
Tânia Perestrelo,
João Ramalho-Santos

Published: August 12, 2015
https://doi.org/10.1371/journal.pone.0135617

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Pluripotency
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Cell differentiation
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Mitochondria
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